Chattanooga Research Site Helping To Study Investigational Celiac Disease Treatment

CeliAction Study Enrolling Patients At ClinSearch

Tuesday, November 12, 2013

ClinSearch Tuesday announced it is participating in a global study to help advance celiac disease research. The CeliAction Study (https://www.celiactionstudy.com/) is a clinical research study that is designed to assess whether an investigational drug can improve the damage in the lining of the intestine caused by traces of gluten contaminating a gluten-free diet. The study will also evaluate whether the investigational drug improves any symptoms of celiac disease.  ClinSearch has begun enrolling participants at its site in Chattanooga.  

Celiac disease is an inherited autoimmune disorder that affects susceptible people of all ages. When people with celiac disease eat certain gluten-containing foods, their immune systems react to the gluten and damages the lining of the small intestine, interfering with their ability to absorb nutrients from the food. Gluten is a plant protein found in foods like wheat, rye and barley.  The immune reaction to gluten triggers uncomfortable symptoms including abdominal pain, diarrhea, joint pain, skin rash and mouth sores. Undiagnosed and untreated, celiac disease can lead to the development of other autoimmune disorders, as well as osteoporosis, infertility, neurological conditions and in rare cases, cancer.

About one in every 100 people in the United States has celiac disease.  The only available option for people with this disease is to attempt try to follow a strict gluten-free diet. 

"While many of those with celiac disease experience some improvement in symptoms after committing to a gluten-free diet, even the slightest exposure to gluten can trigger symptoms and further damage the lining of their small intestines,” said Daniel Leffler, MD, MS, director of Clinical Research at Beth Israel Deaconess Medical Center Celiac Center. “Celiac disease is more than just an upset stomach; the ongoing autoimmune reaction can result in an inability to properly absorb nutrition, which in turn, can lead to long-term serious health issues such as osteoporosis and anemia. Other long-tern complications of the disease, though rare, can include intestinal cancers and lymphoma.” 

“There is a real need to develop new treatment options for people with celiac disease,” said Richard Krause, M.D., site principal investigator, ClinSearch. “That’s why we are so excited to let people here in Chattanooga know that if they have been diagnosed with celiac disease and are struggling to manage their celiac disease with only a gluten-free diet, they may qualify to participate in our research program. While participation is not right for everyone, we have a real opportunity here to advance celiac disease research.”

The CeliAction study is looking for diagnosed celiac patients who are at least 18 years old, on a gluten-free diet for at least 11 months and have experienced at least one moderate to severe symptom of celiac disease in the past month. Qualified participants who are randomized will not be intentionally exposed to gluten during the study and must maintain their gluten-free diet throughout the duration of the study. 

Qualified participants who are randomized into the 12-week long CeliAction Study will receive access to study-related care from qualified physicians. Qualified participants may also receive compensation for time and travel.

The research study is sponsored by Alvine Pharmaceuticals. For more information, visit www.CeliActionStudy.com or call 1-855-3333-ACT


Corker, Colleagues Pledge Support For Fight To Contain Ebola Outbreak

The United States Senate unanimously passed a resolution offered by Senator Bob Corker, ranking member of the Senate Foreign Relations Committee, and Senators Chris Coons (D-Del.), Jeff Flake (R-Ariz.), Robert Menendez (D-N.J.) and Dick Durbin (D-Ill.) recognizing the severe threat posed by the outbreak of Ebola in West Africa and the support provided by the United States government, ... (click for more)

Corker Congratulates Bethany Christian Services On Being Named An “Angel In Adoption”

Senator Bob Corker congratulated Bethany Christian Services of Chattanooga on being recognized as a Congressional Coalition on Adoption Institute 2014 Angel in Adoption for their advocacy of adoption issues. “Bethany Christian Services of Chattanooga has impacted the lives of countless families through their tireless dedication to finding children permanent, loving homes, and ... (click for more)

Man Charged With Killing 3-Year-Old Takes Own Life In County Jail

Justin Dale Bradley died in the Hamilton County jail Saturday morning. Notification was received from the Hamilton County 911 Center at   12:50 a.m. ,   regarding an inmate found unresponsive.   Jail personnel found the male inmate unresponsive in his cell and initiated C.P.R. while notifying Hamilton County Emergency Medical Services. ... (click for more)

Democratic Chairman Roy Herron Announces He Will Not Run For 2nd Term

Democratic Party Chairman Roy Herron announced Saturday at a meeting of the Tennessee Democratic Party State Executive Committee that he would not be seeking a second term as party chairman. “I have been blessed to serve as chairman these past two years, and I owe an enormous debt of gratitude to all of the executive committee members, party officials, staff members, and friends ... (click for more)

You’re Right With Lamar

One of Tennessee’s favorite sons, Davy Crockett, coined an oft-used phrase:  “Be always sure you’re right, then go ahead.” Being sure is quite important, but may be difficult in this election cycle. The Democratic nominee campaigning against Lamar Alexander is a man whose radio ads call for “change,” “fair” taxes and more jobs.  Sounds good, huh?   ... (click for more)

Roy Exum: A Late Garden Walk

Due to a series of pressing events I didn’t get a chance to make my September walk through the garden until yesterday. It is normally my custom to take a stroll on the first day of each new month, looking for the orchids and onions that might appear, so I can award them to those among us who deserve one or the other. So before the temperatures drop, allow me to catch up: AN ORCHID ... (click for more)