Chattanooga Investment Firm, After Selling 2 Prior Businesses, Develops New Sleep Treatment

Thursday, June 6, 2013

A Chattanooga investment firm on Wednesday announced the results of its ADX-NO5 for the company's Phase 2a clinical trial for the treatment of narcolepsy.  

The results were presented at the SLEEP 2013 meeting in Baltimore.

Aerial Biopharma is the third company formed by the successful management team that previously formed Addrenex, which was acquired by Shionogi Pharma in November 2009, and Neuronex, which was acquired by Acorda Therapeutics in 2012.

The investment group for the two completed projects and the current ongoing project is headed by Chattanooga ob/gyn, Dr.

Dave Adair.

Aerial Biopharma was named an inaugural 2013 Life Sciences Awards winner by the Triangle Business Journal and accounting giant BDO.  The award is given to organizations and individuals that reflect power, influence and intellect in the life sciences sector.

A total of 33 patients were randomized and completed both N05 and placebo periods in this double-blind, placebo-controlled, multi-center, crossover study.  The average sleep latency across the four trials on the Maintenance of Wakefulness Test (MWT), an objective measure of the severity of excessive daytime sleepiness, was 11.8 minutes longer with N05 treatment than with placebo (p=.0002).  In addition, N05 was statistically superior on each of the 4 individual MWT trials (sleep latency 9-14.6 minutes longer, p<.001).  

On the Epworth Sleepiness Scale, a subjective patient-completed measure of sleepiness, N05 was superior to placebo following 1 week (p<0.0001) and 2 weeks (p=0.0002) of treatment.    The Clinical Global Impression-Change (CGI-C) rating, a subjective physician-completed overall improvement scale, showed that at 1 and 2 weeks of treatment, 88% and 76% of subjects improved on N05 versus 27% and 39%, respectively, on placebo (p<0.001, p=0.0016, respectively).  N05 was generally well tolerated during the trial.

 

“Despite the availability of treatments, there remains significant unmet medical need for patients suffering from narcolepsy,” said Richard Bogan, MD, chief medical officer and Director, SleepMed Inc., and the leading study author.   “The results of this study suggest that ADX-N05 has the potential to be a significant improvement in treatment.”

 

Moise Khayrallah, PhD, CEO and co-founder of Aerial Biopharma, said, “We are very pleased with the results of the Phase 2a trial and are eagerly anticipating the results of our Phase 2b clinical trial, expected in the third quarter of this year.   Our company is very focused on accelerating the development timeline for ADX-N05 so that we can bring this important potential treatment to patients as soon as possible."


LYNC Logistics Named 1 Of Inc. Magazine’s Best Workplaces For 2019

Chattanooga Chamber Calendar Of Events For May 28-31

Austin Hatcher Foundation Announces New Family Services Coordinator


LYNC Logistics has been named one of Inc. magazine’s Best Workplaces for 2019, its fourth annual ranking in the fast-growing private company sector. Hitting newsstands on May 28 in the ... (click for more)

May 28, East Brainerd Chamber Council Meeting 11:30 a.m. to 1 p.m. The Chattanooga Event Center: 2193 Park Dr. Speaker: Bev Brockman, The Entrepreneurial Mindset $12 May 28, ... (click for more)

The Austin Hatcher Foundation for Pediatric Cancer announces Lauren Kelly has been hired as family services coordinator. Ms. Kelly has a background in multiple roles, including nonprofit fundraising, ... (click for more)


Business

LYNC Logistics Named 1 Of Inc. Magazine’s Best Workplaces For 2019

LYNC Logistics has been named one of Inc. magazine’s Best Workplaces for 2019, its fourth annual ranking in the fast-growing private company sector. Hitting newsstands on May 28 in the June 2019 issue, and as part of a prominent Inc.com feature, the list is the result of a wide-ranging and comprehensive measurement of private American companies that have created exceptional ... (click for more)

Chattanooga Chamber Calendar Of Events For May 28-31

May 28, East Brainerd Chamber Council Meeting 11:30 a.m. to 1 p.m. The Chattanooga Event Center: 2193 Park Dr. Speaker: Bev Brockman, The Entrepreneurial Mindset $12 May 28, Urban League of Greater Chattanooga Annual Entrepreneur Power Luncheon 11:30 a.m. to 1 p.m. The Chattanooga Convention Center: 1150 Carter St. Keynote Speakers: E.J. Reed, Clint Gray ... (click for more)

Breaking News

Person Pulled From Burning Home On Airport Road Saturday Morning

A person was pulled from a burning home on Airport Road on Saturday morning. Chattanooga firefighters were dispatched to 900 Airport Road Lot #92 on a residential structure fire with entrapment at approximately 9 a.m. Incident Commander Lieutenant Jack Babb reported fire and smoke showing upon arrival. Two residents had exited the structure prior to firefighters arrival, but ... (click for more)

Dallas Bay Volunteer Fire Department Saves Boat From Fire Saturday Afternoon

The Dallas Bay Volunteer Fire Department saved a million-dollar boat Saturday afternoon. A boat owner called 911 reporting a boat fire located at the Chattanooga Yacht Club at 9400 North Hickory Valley Road. The Dallas Bay VFD responded by boat and arrived on the scene reporting smoke and flames in the engine area. Firefighters quickly extinguished the fire due to 900 gallons ... (click for more)

Opinion

It Is Outrageous That County School Administration Used Our Tax Dollars For Political Lobbying

Dear Dr. Johnson, The campaign central at HCDE headquarters needs a Tennessee Little Hatch Act study time and education. The heart of the issue is that HCDE utilized our tax dollars to lobby against vouchers with employee time, equipment, and lobby payments. Here is my point, I supported ESA vouchers for Hamilton County, and so did a lot of families that desired parental ... (click for more)

Roy Exum: The Saturday Funnies

With all due reverence and respect for Memorial Day this Monday, The Saturday Funnies knows that those who gave their lives to preserve our freedom deserve not our laughter, but our warm memories of their devotion to our country and our fellow troops. But if you were to venture into a VFW this weekend, or come across two or more of our heroes sharing a toast, it is a safe bet ... (click for more)