The Lookouts fell 3-1 in their playoff opener against the Tennessee Smokies.
Game 2 of the playoffs will be at AT&T Field on Thursday at 7:15 p.m.
Cade Horton was dominant for the Smokies in the opener, allowing only three hits over five scoreless innings. He struck out seven.
The Smokies tallied three runs in the third.
Rece Hinds scored the only Chattanooga run.