Tennessee finishes 7-5 under first-year coach Josh Heupel after downing Vanderbilt in the final game of the regular season.
The Vols won 45-21.
Hendon Hooker had 156 yards and two touchdowns.
Tennessee led 24-0 with a second left in the first half when Vandy connected on a 56-yard Hail Mary to make it 24-7.
Vanderbilt got two running touchdowns in the second half.
Cedric Tillman scored twice for Tennessee and Jabari Small had a TD coupled with several big gains. Jaylen Wright ran in the final TD for the home-standing Vols.
It was the third straight for Tennessee over in-state rival Vanderbilt.