Erlanger Specialists Investigate Use Of Stem Cells To Improve Patient Recovery After Stroke

Thursday, January 23, 2020
A new clinical research study at Erlanger Health System NeuroScience Institute is helping neurology specialists determine if stem cells can improve recovery in patients with chronic disability as a result of an ischemic stroke.  
 
“Post-stroke disability is a major public health issue, with nearly one-half of all stroke survivors left with permanent disabilities as a result of damage to the brain,” said Thomas Devlin, MD, PhD principal investigator at Erlanger NeuroScience Institute.
“Currently, the only acute treatments available to stroke patients are within the first three to 24 hours following the stroke. Beyond this acute phase, there are no existing treatments, aside from rehabilitative treatments, to alleviate the disabilities suffered by stroke patients.”
 
The health system’s partnership in the PISCES IIII study involves researching an investigational drug product made from stem cells, CTX0E03 DP, in hopes it will improve function in stroke survivors following a stroke when blood flow to the brain is blocked, such as by a clot.  The target population for PISCES III is stroke survivors with some residual arm movement who have stabilized following an ischemic stroke six to 24 months prior to treatment, but who still have moderate or moderately severe disability requiring help from others to carry out activities of daily living.
 
PISCES III is a randomized, controlled, phase IIb clinical study in the United States to determine if the drug product can change the degree of dependency and disability in ischemic stroke survivors as measured by the modified Rankin Scale (mRS) six months post-treatment as compared to baseline. The mRS is a 7-point, clinician-reported global measure of disability or dependence upon others in carrying out activities of daily living. A one-point improvement from baseline is considered clinically meaningful as it represents a stroke survivor’s ability to function more independently.
 
A previous phase II clinical trial (PISCES II) showed a mRS response rate (> one-pt improvement from baseline) in 35 percent of ischemic stroke patients at 12 months post-CTX0E03 DP treatment. An even higher mRS response rate (50 percent) was measured at 12 months post-CTX0E03 DP treatment in ischemic stroke patients who had some residual arm movement at baseline.
 
“We are pleased to be involved with this study,” said Dr. Devlin. “Results from PISCES III may offer a new treatment approach for ischemic stroke survivors with long-term disability.” 
 
Facts about Ischemic Stroke
-  Stroke is the fifth leading cause of death.
-  Stroke is the leading cause of long-term disability in the United States. 
-  Nearly 800,000 people in the United States have a stroke each year – 87 percent are ischemic strokes in which blood supply to the brain is blocked. 
-  Some stroke survivors recover completely or with minor impairment - 40 percent experience moderate to severe impairments that require specialized care.
-  Annual costs for stroke survivors in the United States are estimated to be $34 billion, including health care costs, medications and lost productivity.
 
To learn more about this trial and/or determine eligibility, visit the PISCES III trial website: www.pisces3.org.
 
Additional information about the study can be found at clinicaltrials.gov using the identifier NCT03629275..

Austin Hatcher Foundation To Host 13th Annual Celebration Of Life And Hope

Officials Celebrate 1-Year Partnership To Help Those With Mental Health Crises

Hamilton Medical Center Offering Robotic-Arm Assisted Joint Procedures


Two weeks before its 13th annual “Celebration of Life and Hope” virtual event on Saturday, Oct. 10, the Austin Hatcher Foundation for Pediatric Cancer will also host an in-person Pre-Party with ... (click for more)

Erlanger Behavioral Hospital on Monday celebrated a one-year partnership with the Hamilton County Sheriff’s office, Chattanooga Police Department and Amerimed EMS to provide psychiatric transportation ... (click for more)

Hamilton Medical Center is offering a robotic technology that allows surgeons to personalize total knee and total hip replacement procedures. HMC is the only hospital in Northwest Georgia using ... (click for more)



Living Well

Austin Hatcher Foundation To Host 13th Annual Celebration Of Life And Hope

Two weeks before its 13th annual “Celebration of Life and Hope” virtual event on Saturday, Oct. 10, the Austin Hatcher Foundation for Pediatric Cancer will also host an in-person Pre-Party with limited admittance on Sept. 25 from 6-8 p.m. The evening’s events include a socially distanced cocktail party and special guided tours of the foundation’s new Education Advancement Center. ... (click for more)

Officials Celebrate 1-Year Partnership To Help Those With Mental Health Crises

Erlanger Behavioral Hospital on Monday celebrated a one-year partnership with the Hamilton County Sheriff’s office, Chattanooga Police Department and Amerimed EMS to provide psychiatric transportation to those in need during a mental health crisis. Hamilton County is only the second county in Tennessee to have this service. It is the Sheriff's Department that is responsible ... (click for more)

Breaking News

Former County EMT Charged With Vehicular Homicide Is Back Out Of Jail After Pretrial Services "Error"

A former county EMT accused of vehicular homicide was taken into custody in court on Monday based on five alleged violations of his pretrial release. But Justin Whaley was back out of jail on Wednesday after it was agreed that the report of the violations was unfounded. His attorney, Lee Davis, said, " The report filed by Pretrial Services was in error. There was no alcohol ... (click for more)

Sports Wagering Committee Of State Lottery Board Conditionally Approves Licenses For 1st Group Of Sports Betting Operators

The Sports Wagering Committee of the Tennessee Education Lottery Board of Directors on Wednesday conditionally approved licenses for the first group of sports betting operators in Tennessee. The committee also approved its first supplier application and 26 additional vendor applications and announced follow-up meetings Oct. 5 and 16 to take up more applications and review additional ... (click for more)

Opinion

Earl Freudenberg Remembers Bettye Parker

One of the most patriotic individuals I have ever known has passed away. Bettye Parker died Tuesday after a short illness. At Bettye's request there will be no memorial service. Bettye ran Bettye Parker Realty on Highway 58 for as long as I can remember. She handled thousands of property transactions. Her son, Paul Parker, also became involved in real estate and is the real ... (click for more)

Roy Exum: Floyd - The Whole Truth

I have been in the news business as a writer my entire life and the main cornerstone of any story is the truth. Later, as an opinion writer, I was enabled to interject exactly that, my “opinion,” which sometimes will differ from that of the readers, yet the strongest point in all arguments is fact. As a vociferous reader, I am becoming more concerned over the bias in the mainstream ... (click for more)