The Tennessee Lady Vols came from 18 back in the third quarter to a point behind early in the fourth, but sputtered the rest of the way to lose to Virginia Tech in the Sweet 16.
The Lady Vols lost 73-64.
Guard Georgia Amoore, the ACC Player of the Year, was the difference maker, scoring 29 points.
Virginia Tech, which took a close win earlier in the season at Thompson-Boling Arena, led by five at the end of the first quarter and by 13 at the half.
An Elizabeth Kitley layup made it 40-22 with just under nine minutes to go in the third quarter.
The Vols turned to a full court press that brought them to within one at 53-52 after a Jasmine Powell three pointer from the corner.
Then the Hokies went on a run of their own that put the game out of reach.
Jordan Horston scored 17 and Rickea Jackson.
The Lady Vols finish 25-12.