Nashville-based TailGate Brewery will open at the location by the Chattanooga Choo Choo formerly operated by Terminal Brewhouse.
It will be the fifth Tailgate location after Germantown, Bellevue, East Nashville and Music Row.
Terminal Brewhouse recently announced its closing, citing issues with the lease.
Tailgate founder Wesley Keegan has bought the South Market Street property.
He said, "It’s been our loudest pull out of Nashville, ‘Come to Chattanooga!’ And boy we’ve tried! When we heard this building was available we were hopefully, optimistically, pessimistic that we could finally make it happen!”